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The promise of selective MET inhibitors in non-small cell lung cancer with MET exon 14 skipping

SUMMIT: Tirzepatide and heart failure with preserved ejection fraction SUMMIT (Packer et al., NEJM 2024, NEJMoa2410027, PMID 39555826) randomized 731 patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 to tirzepatide up to 15 mg/week or placebo, with a median follow-up of 104 weeks

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Store reconstituted vials refrigerated at 2-8 degrees Celsius, and most sources report stability for 30-60 days once reconstituted, provided you avoid repeated freeze-thaw cycles

Compounded semaglutide is custom-made medication which can be helpful during shortages or when the patient needs a custom dose or formulation, but its consistency and safety are not approved by the FDA